Wonder if anyone has had this trouble. I'm on Cymbalta 60mg, which is working, but my heart rate has gone up about 10bpm, not a big deal but I'm a runner and when I run it goes up very quickly so that I can't make any gains in endurance or pace, I'm walking most the time right now 'cause I'm just out of breath at a jog! And it's raised by diastolic BP a bit too. So the doc wants to try 40mg and see what happens. Anyone else had success with this? I feel like all SNRIs are going to raise my HR because of the nor-epinephrine effect.