I was prescribed cyclobenzaprine for severe neck and shoulder tightness. The PA along with the pharmacist cautioned about it's effects and recommended starting with half pills etc. As I did this, I found that even with a full dose I found zero affect on my muscles and zero affect on my state of mind (drowsiness, "buzzed" etc). I could have saved money and taken Tic Tacs. I now am taking Soma twice a day which does seem to minimize the pain and tightness. I only take Crestor and Niaspan for cholesterol and occasional Lodine for my back. Other than the miscellaneous Tylenol-3 for a root canal or something, I do not have any history of drug use with myself or my family. My question is this: being an athletic 185# male, full doses of the above have minimal affects with my muscles where as my co-worker who is 250#-275# is floored with even half does. What are the stats on resistance to these types of medication and what would cause this? Being a well-degree'd radiochemist be as technical as you want.
Welcome to the weird club. Sometimes, for whatever reason, drugs just plain don't work. Sometimes you have a super-high tolerance for no discernible reason. Sometimes you get knocked flat by something you never would have expected.
Example using muscle relaxants: like you, cyclobenzaprine does nothing for me. I can take five at once and... nothing. But Flexeril? I take one (which is half a dose) and I'm out like a lightbulb.
Bodies are weird, dude. It's just that simple.
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