... tab.500 mg 4x day. I suffer with excessive sweating. I had my blood checked. My cortisol levels are HIGH (160-75). I read on the Internet that sulfasalazine can cause high cortisol. I have been under a lot of stress the past 18 months taking care of my 92 year Mother and 89 year old Aunt. I work 3 days a week in an office. My sleep has also suffered. Has anyone else experienced high cortisol levels? The sweating is driving me crazy. HELP! How did you solve your problem?