I had a cortisone shot in my shoulder and it started helping very quickly then a few days later I realized my back pain, knee pain were very low. Least pain I've been in for years. Also my psoriasis never flared up for 2 months, it was about one and a half months till my back pain returned, my shoulder is still good. I had this done right before a vacation and i actually hiked with my family, down into a canyon, something that I normally could never do. Anyone ever have this happen?