I do not qualify for the everyday injections that a primary MS patient self induces. The Neurologist suggested a procedure which has been used for years for MS patients like myself which may work or not. An IV of cortisone is administered to me in a hospital 3 straight days in a row. Then once a month after those 3, I go in for an IV. I am seriously concerned about the side effects of cortisone though I do not know if I am allergic to it because I never been on cortisone before. Is MS considered an "inflamatory" disease and known to be treated by cortisone in this manner or procedure?
Corticosteroids are prescribed to patients during a MS relapse to reduce its severity and duration. They can ease the inflammation at affected sites. Corticosteroids treat the symptoms of MS not the cause. MS is an auto-immune disease, its symptoms include inflammation. (Hope that answers your question?)
You may find these sites useful.
I have had MS for 30 years and use Intravenous Methylprednisolone (IVMP) for every exacerbation exclusively. The accepted protocol is 1000mg/day for 3 days. When things are really bad this can be extended to 5 days. For this short pariod you don't need a taper. Low dose pred for extended periods is worthless and dangerous. I know of no papers which have suggested otherwise. I stoped research a few years ago but a recent search netted:
International MS journal 2009 Jun;16(2):42-6.
Spotlight series: pivotal trials through today's knowledge--adrenocorticotrophic hormone.
University of Arizona, College of Medicine, Tucson, Arizona 85724, USA.
Forty-five years ago the first large multicentre, randomized, double-blinded, controlled trial of a potential therapy for multiple sclerosis (MS) was completed testing corticotrophin versus placebo. It demonstrated the feasibility of such a trial in an illness which is as variable, from patient to patient, as MS. Adrenocorticotrophic hormone was soon replaced by intravenous methylprednisolone (IVMP) as therapy for acute exacerbations, to control acute inflammatory responses. Long-term therapy with corticosteroids is fraught with complications. Pulsed IVMP has been widely used as an alternative, but few formal studies have been done. One, however, suggested that treated patients had less brain atrophy, and further study of this technique may be indicated.
PMID: 19671367 [PubMed - indexed for MEDLINE]
William Sibley wrote the original "Therapeutic Claims in Multiple Sclerosis" and you can find reference to the "pulse" therapy as far back as 1996.
Believe me it works fine if handled well and sparingly. I've read some post here that seem to ignore medical research.
Yess MS is an inflammatory condition. Flus, colds, allergies, asthma can exacerbate the disease, causing a pseudo relapse. Prednisone is used exclusively for relapses. Any other use is nonsense, dangerous and useless. Ask your neurologist about Rebif. It has been shown to be helpful for "secondary progressive" MS. The other disease modifying drugs are useful only for "Relapsing Remitting" MS, which greater than 75% of persons have. Secondary MS usually follows the Relapsing Remitting type as a progression of the disease. Are you sure you were not diagnosed with "Primary Progressive"?
- Cortisone Information for Consumers
- Cortisone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Cortisone (detailed)
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