What is the data regarding cold sores while taking Otezla? I've been taking Otezla for 4 months. It's given me 80% improvement for atopic dermatitis. I've had continuing cold sores on my lips since starting the medication in February 2018. One heals and another appears. They last about 2-3 weeks then heal and one or two appear after 2 weeks. I've had cold sores before but not to this extent. Is Otezla causing this?