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Colchicine - what is the correct dosage?

Responses (1)

Marvell 24 Nov 2009

This is the dosing schedule for colchicine:

Colchicine Dosing Information

Usual Adult Dose for Acute Gout:

Parenteral:
Initial (IV): 2 mg one time, followed by 0.5 mg IV every 6 hours until a satisfactory response is attained or 3 mg one time or 1 mg one time, followed by 0.5 mg once or twice a day if needed. Do not exceed a total of 4 mg/day or for one course of treatment. If pain recurs, it may be necessary to give 1 to 2 mg/day for several days.

Oral:
Initial: 1 to 1.2 mg orally one time, followed by 0.5 to 1.2 mg orally every 1 to 2 hours until pain is relieved or nausea, vomiting or diarrhea occurs. The total dose needed to control pain and swelling is typically 4 to 8 mg. Do not exceed 8 mg per day.

Usual Adult Dose for Gout -- Prophylaxis:

Oral:
0.5 to 0.6 mg orally once a day for 3 to 4 days a week (<1 attack/year).
0.5 to 0.6 mg orally once a day (>1 attack/year).
Severe cases may require 1 to 1.8 mg/day.

Usual Adult Dose for Biliary Cirrhosis:

0.6 mg orally twice a day.

Usual Adult Dose for Sarcoidosis:

0.6 mg orally twice a day.

Usual Adult Dose for Pseudogout -- Prophylaxis:

0.6 mg orally twice a day.

Usual Adult Dose for Fibromatosis:

Initial: 0.6 to 1.2 mg orally once a day each day for the first 1 to 2 weeks.

Maintenance: 0.6 to 1.2 mg orally once a day 1 to 2 times per week is often used to prevent recurrence of fibromatosis.

Usual Adult Dose for Aphthous Stomatitis -- Recurrent:

0.6 mg orally 3 times a day. Some patients may respond to 0.6 mg orally once a day, however, this is in the minority of cases.

Usual Adult Dose for Behcet's Disease:

0.5 to 1.5 mg orally once a day.

Study (n=116)
Dosage adjusted to body weight:
<50 Kg 1 mg daily
50 to 59 Kg 1 mg and 1.5 mg on alternate days
60 to 75 Kg 1.5 mg daily
76 to 84 Kg 1.5 and 2 mg on alternate days
>=85 Kg 2 mg daily

Usual Adult Dose for Familial Mediterranean Fever:

1.2 mg to 2.4 mg orally daily, administered in 1 or 2 divided doses

The dose should be increased as needed to control disease and as tolerated in increments of 0.3 mg/day to a maximum recommended daily dose. If intolerable side effects develop, the dose should be decreased in increments of 0.3 mg/day.

Usual Adult Dose for Constipation -- Chronic:

Study (n=16)
0.6 mg orally three times daily for 4 weeks

Usual Adult Dose for Sweet's Syndrome:

0.6 mg orally twice daily.

Usual Geriatric Dose for Behcet's Disease:

Oral: 0.5 to 0.6 mg orally daily

The dose may be titrated upward while the patient is observed for signs of toxicity.

Usual Geriatric Dose for Biliary Cirrhosis:

Oral: 0.5 to 0.6 mg orally daily

The dose may be titrated upward while the patient is observed for signs of toxicity.

Usual Geriatric Dose for Sarcoidosis:

Oral: 0.5 to 0.6 mg orally daily

The dose may be titrated upward while the patient is observed for signs of toxicity.

Usual Geriatric Dose for Pseudogout -- Prophylaxis:

Oral: 0.5 to 0.6 mg orally daily

The dose may be titrated upward while the patient is observed for signs of toxicity.

Usual Geriatric Dose for Aphthous Stomatitis -- Recurrent:

Oral: 0.5 to 0.6 mg orally daily

The dose may be titrated upward while the patient is observed for signs of toxicity.

https://www.drugs.com/mtm/colchicine.html

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