I have been on duloxetine, venlafaxine for over 20years. Recently tried sertraline, escitilipram, pregabalin. These have helped my OCD 70% but none have ever help d my severe anxiety and low mood. I am so desperate to get better, I read all the books try cat etc etc but I am so nervous I find everything overwhelming, lost a good job, marriage and feel hopeless. I am now 47 and my psychiatrist wasn’t keen to change but clearly SSRI/SRNI aren’t helping enough. I am hopeful but so scared when changing if they just don’t work. Thank you.