The FDA. The FDA has assigned a pregnancy risk category to each drug based on available clinical and preclinical information gained during studies. The five categories ( A. B. C, D and X) reflect a drugs potential to cause birth defects. Although drugs should ideally be avoided during pregnancy, sometimes they are necessary. This rating system permits rapid assessment of the risk-benefit ratio. This is based off clinical studies. many medications are placed into Category C because there are just not enough studies done to show safety during pregnancy. Drugs in category A are generally considered safe and drugs in X are contraindicated.
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