I was just prescribed this after my upper gi endoscopy/with ultrasound showed excess bile in my stomach, I had my gall bladder out in April 2012 and had a great recovery from it and thought my IBS-diarrhea was over ... well, it isn't and it has come back with a nasty attitude! So, my doc prescribed Questran 2 packets a day. I started out with one packet and on day two I was so constipated it took almost 36 hours to get my bowels moving again :( I was not happy ... so what I'm doing now, is taking one packet divided into three doses per day ... or will this not work? Does it have to be taken all at one time in order to be effective?