My psych told me that you can't build up a tolerance to an antidepressant. I've been depressed most all of my life; hence since my adult life I've been on many different medications, seen many different doctors. Sometimes a bunch of negative situations blow me right of the water and that's when either my dosage or the medication needs adjusting and then my emotions seems to level off to normal again. Has anyone experienced this before? He just prescribed Remeron tonight.