... has an elimination half-life of ca. 3 hours (like amoxicillin). The protein binding is ca. 65%. The local bioavailability of cefixime is unknown. The half-life of ca. 3 hours doesn't justify the application of "twice daily". Besides, the max. daily dose is 400 mg, it can be given in one time 400 mg (a high intake dose at one time causes high side effects) or two times 200 mg (more moderate intake dose of 200 mg). Cefixime three times a day, e.g. 3 dd 100 mg is definitely better. THX