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Can you tell me some informations about pharmacokinetics of cefalosporins-third generation?

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Rajive Goel 23 Apr 2010

Third-generation cephalosporins have a broad spectrum of activity and further increased activity against Gram-negative organisms. Some members of this group (in particular, those available in an oral formulation, and those with anti-pseudomonal activity) have decreased activity against Gram-positive organisms. They may be particularly useful in treating hospital-acquired infections, although increasing levels of extended-spectrum beta-lactamases are reducing the clinical utility of this class of antibiotics. They are also able to penetrate the CNS, making them useful against meningitis caused by pneumococci, meningococci, H. influenzae, and susceptible E. coli, Klebsiella, and penicillin-resistant N. gonorrhoeae. Since 2007, third-generation cephalosporins (ceftriaxone or cefixime) have been the only recommended treatment for gonorrhea in the United States.[13]

* Cefcapene
* Cefdaloxime
* Cefdinir (Omnicef, Kefnir)
* Cefditoren
* Cefetamet
* Cefixime (Suprax)
* Cefmenoxime
* Cefodizime
* Cefotaxime (Claforan)
* Cefovecin (Convenia)
* Cefpimizole
* Cefpodoxime (Vantin, PECEF)
* Cefteram
* Ceftibuten (Cedax)
* Ceftiofur
* Ceftiolene
* Ceftizoxime (Cefizox)
* Ceftriaxone (Rocephin)

Third-generation cephalosporins with antipseudomonal activity

* Cefoperazone (Cefobid)
* Ceftazidime (Fortum, Fortaz)

The following cephems are also sometimes grouped with third-generation cephalosporins:

* Oxacephems: latamoxef (moxalactam)

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