You should not eat after taking your first dose. In fact, I've found that xyrem does not work nearly as well if you've eaten too recently before taking it (as the last comment pointed out.) Also - it's very easy for me to take my first dose and fight through it's onset if I don't lie down right away. For that reason, it's much more effective if you take it and lie down right away. Even if you don't feel tired, it will work much better than if you continue to do anything (including eating) after taking it. Especially because the effects can set in suddenly, it's not the safest choice to eat or continue to do anything other than lying down where you will be sleeping. Even when I wake up in the morning, I can sometimes be a little groggy/clumbsy from the medicine. It's best to leave a full 4 hours for sleeping after each dose.
- Xyrem Information for Consumers
- Xyrem Information for Healthcare Professionals (includes dosage details)
- Side Effects of Xyrem (detailed)
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