i have to take yasmin(oral contraseptive)for bleeding during the month and topo max for migrain. i wanted to know they interact each other or not?
Interactions between your selected drugs
ethinyl estradiol ↔ topiramate
Applies to: Yasmin (drospirenone/ethinyl estradiol), Topamax (topiramate)
ADDITIONAL CONTRACEPTION RECOMMENDED: Efficacy of oral contraception may be decreased by concomitant use with topiramate. The mechanism of action appears to be increased metabolism of the estrogenic component of the oral contraceptive. In a pharmacokinetic study with topiramate 800 mg/day, ethinyl estradiol clearance increased by 47% (range 13% to 107%), while norethindrone was unaffected. Although this has not been reported with mestranol, the likelihood of an interaction should be considered.
MANAGEMENT: Patients taking oral contraceptives and topiramate should be warned of the potential for decreased efficacy of the oral birth control, counseled about the use of additional pregnancy prevention methods, and advised to report any changes in bleeding patterns to their clinician. Some experts have recommended a higher dose contraceptive; however, no specific recommendations are available. Intrauterine systems are unlikely to be significantly affected because of their local action.
Other drugs that your selected drugs interact with
Topamax (topiramate) interacts with more than 200 other drugs.
Yasmin (drospirenone/ethinyl estradiol) interacts with more than 400 other drugs.
Interactions between your selected drugs and food
ethinyl estradiol ↔ food
Applies to: Yasmin (drospirenone/ethinyl estradiol)
The coadministration with grapefruit juice may increase the bioavailability of oral estrogens. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. In a small, randomized, crossover study, the administration of ethinyl estradiol with grapefruit juice (compared to herbal tea) increased peak plasma drug concentration (Cmax) by 37% and area under the concentration-time curve (AUC) by 28%. Based on these findings, grapefruit juice is unlikely to affect the overall safety profile of ethinyl estradiol. However, as with other drug interactions involving grapefruit juice, the pharmacokinetic alterations are subject to a high degree of interpatient variability. Also, the effect on other estrogens has not been studied.
- Yasmin Information for Consumers
- Yasmin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Yasmin (detailed)
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