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Can we give me some information about grey baby disease?thanks?

Responses (1)

itsmetoo2 29 Dec 2009

Found this on the net and I think it explains it pretty good.

Grey baby syndrome :

The grey baby syndrome is a rare condition almost exclusively seen in neonates and very young infants receiving high doses of CHLORAMPHENICOL.

Toxic blood levels of chloramphenicol occurs due to :

inadeqaute conjugation of chloramphenicol with glucuronic acid because of inadequate activity of glucuronyl transferase in the newborn liver and
decreased renal excretion of the unconjugated chloramphenicol leads
The infant is cyanosed, is acidotic, has cold peripheries and has the signs of all of marked hyponia, poor feeding, vomiting, loose stools and a distended abdomen free discount card

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