I seem to have medication-resistant depression as I am constantly changing medications or dosages with little improvement in my depression. I also have IBS-M. I read that SSRI's are best for IBS-C and Tricyclic Anti-depressants are best for IBS-D. Could combining the two medications help with both the depression and IBS-M?
Ditto on 1bobbielou's post--that is not something you want to do. If you are trying to decide between which ONE of the two to take, you should talk to your doctor. Venlafaxine (Effexor) affects both serotonin and norepinephrine, whereas tricyclics affect all 3 of the monoamines (serotonin, norepinephrine, AND dopamine).
As I said already, it's best to speak with your doctor about this one... particularly as either may potentially exacerbate your problem. Also, since Effexor is not an SSRI, however, you might want to look-up IBS-M and SNRIs. My instinct tells me that in terms of the actual type of antidepressant you take, your diet and water intake are going to affect the symptoms of your IBS in a much more pronounced/significant manner. Everybody is different as well, so always be prepared for the unexpected!
Good luck with your situation... I hope it all works out well for you in the end!
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