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Can sumatripan be taken with sertraline (depression) and lamotrigine (generic for seizures)?

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suzanne66 10 Mar 2010

Care needs to be taken when triptans (eg Sumatriptan) and selective serotonin reuptake inhibitors (SSRIs eg sertraline) are taken together.

There is a risk of developing Serotonin syndrome. Serotonin syndrome is a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells.

There is also possible potentiation of side-effects with sertraline and lomotrigine which could result in decreased mental alertness, drowsiness and breathing difficulties.

If these drugs are given together it must be under careful supervision.

See: https://www.drugs.com/interactions-check.php
https://www.drugs.com/enc/serotonin-syndrome.html

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