After a lifetime of severe depressive episodes and mood disorders, and trying more medications than I can remember, my mom (bipolar II) started Saphris at the end of September as a last ditch effort during a period of suicidal ideation. She'd had no relief in symptoms at all for the past 6 years, and within 5 days on 5mg of Saphris, she was a new woman... It lasted for a full 13 weeks, and then it just stopped working. Nothing else changed, and she's fully compliant with taking her meds. Her MD upped her dose to 10mg, and it's having no effect on her whatsoever. Has anyone else experienced this? Has anyone else had a great initial response to the med, but then it simply stopped working?