My mother-in-law said the dose of 2-10 mg pills per day made her feel "drunk". Her doctor kept reducing til it got down to 1/2 pill per day and it still seems effective for her pain but she is so depressed since she started taking it. (The pain is not completely gone, but managable). Alcohol shots lasted for many yrs. She is 89 yrs old & doesn't want to do another Alcohol shot)