Hello Jordancarmona. Bupropion (wellbutrin) can be taken with Alprazolam (xanax) You'll have to pay attention to several possible side effects. bupropian will and does often cause or help to cause insomnia, and that will counteract the sedation, calming effects that alpazolam/xanax gives you. Bupropian also does tend to make you more anxious, nervous, and that also takes away from the way that xanax works. What I mentioned might not even happen to you, its just side-effects reported when these two drugs are taken together.best wishes to you.
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Posted 26 Jan 2016 • 2 answers