Interactions between your selected drugs
ibuprofen ↔ duloxetine
Applies to: ibuprofen, Cymbalta (duloxetine)
MONITOR: Serotonin reuptake inhibitors (SRIs) may potentiate the risk of bleeding in patients treated with ulcerogenic agents and agents that affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. The tricyclic antidepressant, clomipramine, is also a strong SRI and may interact similarly. Serotonin release by platelets plays an important role in hemostasis, thus SRIs may alter platelet function and induce bleeding. Published case reports have documented the occurrence of bleeding episodes in patients treated with psychotropic agents that interfere with serotonin reuptake. Bleeding events related to SRIs have ranged from ecchymosis, hematoma, epistaxis, and petechiae to life-threatening hemorrhages. Additional epidemiological studies have confirmed the association between use of these agents and the occurrence of upper gastrointestinal bleeding, and concurrent use of NSAIDs or aspirin was found to potentiate the risk. Preliminary data also suggest that there may be a pharmacodynamic interaction between SSRIs and oral anticoagulants that can cause an increased bleeding diathesis. Concomitant administration of paroxetine and warfarin, specifically, has been associated with an increased frequency of bleeding without apparent changes in the disposition of either drug or changes in the prothrombin time. Bleeding has also been reported with fluoxetine and warfarin, while citalopram and sertraline have been reported to prolong the prothrombin time of patients taking warfarin by about 5% to 8%.
MANAGEMENT: Caution is advised if SRIs or clomipramine are used in combination with other drugs that affect hemostasis. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
Other drugs that your selected drugs interact with
ibuprofen interacts with more than 200 other drugs.
Cymbalta (duloxetine) interacts with more than 500 other drugs.
Interactions between your selected drugs and food
duloxetine ↔ food
Applies to: Cymbalta (duloxetine)
GENERALLY AVOID: Use of duloxetine in conjunction with chronic alcohol consumption may potentiate the risk of liver injury. Duloxetine alone can increase serum transaminase levels. In clinical trials, 0.3% of patients discontinued duloxetine due to liver transaminase elevations. The median time to detection was about two months. Three duloxetine-treated patients had liver injury as manifested by transaminase and bilirubin elevations, with evidence of obstruction. Substantial intercurrent ethanol use was present in each of these cases, which may have contributed to the abnormalities observed. Duloxetine does not appear to enhance the central nervous system effects of alcohol. When duloxetine and ethanol were administered several hours apart so that peak concentrations of each would coincide, duloxetine did not increase the impairment of mental and motor skills caused by alcohol.
MANAGEMENT: Due to the risk of liver injury, patients prescribed duloxetine should be counseled to avoid excessive use of alcohol. Duloxetine should generally not be prescribed to patients with substantial alcohol use.
in 1975 I have a subtotal gastrectomy, my concern for you is that Ibuprofen already can cause gastric irritation and in some people can cause a G.I. bleed I don't know what Cymbalta and alcohol would do but the fact that it has an effect on your mental status then I would question whether it would be a good idea for you to drink alcoholic beverages with the combination of any of these, it's just my opinion but I would rather have you be safe than for you to have any problems at all, before I would go as far as to do it I would talk to the doctor or pharmacist and see what they have to say, your safety is paramount to me, I want you to be the very best you can be, feel free to keep us posted, this question may very well come up again and it would be an educational piece of information. Take good care
Hi nicoledawn. Well inregards to alcohol, its not recommended. Possibly, and very likely it will damage your liver. And it will help to nullify any chance the possible healing effects that cymbalta as a antidepressant was created for. Thats more or less the rule. I would use caution in regards to alcohol when using medications, especially those labelled for psychiatric use. In almost every case-medication, alcohol use is highly not recommended.I'd stay away from the alcohol, the adverse effects as a result might be very serious. best wishes to you though, hope that the cymbalta is helping or going to help you.
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