Under the Interactions Checker a moderate condition has been reported between the 2 meds.
lprazolam ↔ fluoxetine
MONITOR: Fluoxetine may increase plasma alprazolam concentrations, decrease alprazolam clearance, and increase the elimination half-life of alprazolam. The mechanism may be related to inhibition of CYP450 3A4 microsomal drug metabolism. This combination may impair psychomotor performance and reports have suggested that the risk of cardiac toxicity such as bradycardia may be increased.
MANAGEMENT: If fluoxetine and alprazolam must be used together, close observation is recommended for increased adverse effects. Patients should be warned about excessive drowsiness and potential adverse effects on their psychomotor and driving skills.
Take care, best wishes!
- Fluoxetine Information for Consumers
- Fluoxetine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fluoxetine (detailed)
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