No, Diphenhydramine should not cause liver or kidney damage if given at recommended doses (ie 25mg to 50mg up to 4 times day) for a long period of time. However long term use of diphenhydramine is not recommended.
For more information visit : https://www.drugs.com/cdi/diphenhydramine-sleep-aid-orally-disintegrating-tablets.html
- Diphenhydramine Information for Consumers
- Diphenhydramine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Diphenhydramine (detailed)
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