My wife was diagnosed with GBM IV on Jan 27, 2011 followed by a surgery on Jan 31, 2011. She has been through 42 days of Chemo and 30 days of simultaneous Radiation. This was followed by 12 x 5-days monthly cycle of temadol. However after 6 weeks of the last Temadol dose the tumor reappeared and with a very explosive growth. Within two weeks she was given the 1st dose of Avastin which will be followed by 3 doses of Avastin every two weeks.