My husband has to take kadian for chronic pain. He also is on lexapro for depression and cymbalta for pain. Lately he is acting like a completely different person. He acts a little out of it, looks like he is falling asleep, but wont! He kind of spasms, or talks to himself. He gets kind of defensive if anyone says anything, but doesn't remember a word the next day. I have seen people OD, and that doesn't SEEM to be the case. He has been on this medication for a long time, why is this happening now?