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Can a person drink cymbalta and gabapentin at a different time is it safe?

Responses (1)

LaurieShay 2 May 2011

Hey candygirl,

I'm not sure I understand your question. Are you asking if it is ok to drink alcohol, and take Cymbalta and gabapentin at the same time?

The following are the warnings for use of these substances:

ethanol ↔ gabapentin
Applies to: Alcohol (contained in alcoholic beverages) (ethanol), gabapentin

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

ethanol ↔ duloxetine
Applies to: Alcohol (contained in alcoholic beverages) (ethanol), Cymbalta (duloxetine)

GENERALLY AVOID: Use of duloxetine in conjunction with chronic alcohol consumption may potentiate the risk of liver injury. Duloxetine alone can increase serum transaminase levels. In clinical trials, 0.3% of patients discontinued duloxetine due to liver transaminase elevations. The median time to detection was about two months. Three duloxetine-treated patients had liver injury as manifested by transaminase and bilirubin elevations, with evidence of obstruction. Substantial intercurrent ethanol use was present in each of these cases, which may have contributed to the abnormalities observed. Duloxetine does not appear to enhance the central nervous system effects of alcohol. When duloxetine and ethanol were administered several hours apart so that peak concentrations of each would coincide, duloxetine did not increase the impairment of mental and motor skills caused by alcohol.

MANAGEMENT: Due to the risk of liver injury, duloxetine should generally not be prescribed to patients with substantial alcohol use.

gabapentin ↔ duloxetine
Applies to: gabapentin, Cymbalta (duloxetine)

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities

So drinking while taking Cymbalta and gabapentin is not a good practice.

If I have misunderstood your question, I am sorry.

Best wishes,

Laurie

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