Yes, especially fasting blood glucose. Diabetic patients may need to be monitored carefully.
This from https://www.drugs.com/pro/niaspan.html
"... 5.3 Laboratory Abnormalities
Increase in Blood Glucose: Niacin treatment can increase fasting blood glucose. Frequent monitoring of blood glucose should be performed to ascertain that the drug is producing no adverse effects. Diabetic patients may experience a dose-related increase in glucose intolerance. Diabetic or potentially diabetic patients should be observed closely during treatment with Niaspan, particularly during the first few months of use or dose adjustment; adjustment of diet and/or hypoglycemic therapy may be necessary."
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