My dermatologist just started me on samples of the Calcipotriene ointment a week ago and I'm not seeing any improvement yet. I've been on topical meds which had steroids and had to stop these because it was becoming harmful to my skin. I've had plaque psoriasis for a year now and cannot seem to find anything that will clear it up. My dermatologist brought up using Humira but I've been told by her and a pharmacist that this will compromise my immune system. So I'm using the Calcipotriene along with an otc ointment which has coal tar in it but like I have mentioned, I'm not seeing any improvement yet...