Can Buspar make me feel worse? I've always had pretty bad anxiety for as long as I can remember. Recently my doctor put me on buspar for it. Here's the catch. Instead of slowly getting me on the medication, he prescribed me to take 15MG twice daily. I've only been taking the meds for four days. I believe this is making me feel 10 times worse and I feel like I'm going crazy. Also, I believe my depression and feeling of isolation have gotten significantly worse on this medication. I think I'm going to stop taking the meds altogether and go back to see my doctor. Anyone else had a similar issue?