... zoloft, it worked for another 4 -5 years. I then went to wellbutrin sr. That worked for maybe 5 yrs. I forget sometimes because it was quite a few years ago. I should also mention I did not seek help until I was 35 or 26. I am now on Effector 300 MG and wellbutrin 300mg. This combination also worked for about 10 or 11 yrs. I have recently been having 2 to 3 week episodes if depression. I am so frustrated, this has taken many years of my life from me. Is there anyone who can shed some light my way. Thanks, Belinda
Hi, Belinda! You sound so very miserable ~ I'm sorry.
There are two types of depression (more really, but let's leave it at two): situational depression that occurs after a life event such as a divorce, job loss, or loss of a loved one, etc., and clinical depression which is a lifelong chemical imbalance of the brain's neurotransmitters.
Modern antidepressants can increase the amount of these chemicals in the brain and enable the brain to better utilize them but they have a naughty little habit of *pooping out* after years in many cases.
It sounds like this has happened to you several times, but the good news is that there are many new and good medications on the market and coming to market shortly.
Consult with your doctor, or better yet psychiatrist, about possibly switching to one of them
Wish I could give you a magic bullet but I hope this has helped some.
My best wishes, Wildcat
Hi Belinda! Just to share out, Lamictal 200mg takes care of my anxiety and OCD, Welbutrin SR 100mg tending the depression, and Seroquel 25mg for sleep have been a good balance for me. I also have Chlorazepate 3.75mg as needed for breakthrough anxiety and or migraines, but with the other meds I basically just use that for migraines so I'm in a good balance overall so far, hope this helps, hang in there!
Try adding L-5-methylfolate 1mg daily to your regimen or the Rx version Deplin 7.5 and 15mg tablets but those dosages are too high for people who don't have the MTHFR gene mutation so I would take half a 7.5 twice a week if I had Deplin but thats just my opinion. This form of folate (not folic acid) helps your brain make the neurotransmitters that Effexor and Wellbutrin inhibit the reuptake of so they may work better with more of the NE, 5HT and DA but talk to your Dr or pharmacist before, I prefer asking a pharmacist about things like this as they specialize in drugs
- Wellbutrin Drug Information
- Wellbutrin SR Drug Information
- Zoloft Drug Information
- Bupropion Drug Information
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 7 Aug 2014 • 1 answer
Posted 22 Nov 2015 • 3 answers
Posted 3 Mar 2016 • 2 answers
Posted 17 Apr 2016 • 3 answers
Posted 26 Apr 2016 • 14 answers