... zoloft, it worked for another 4 -5 years. I then went to wellbutrin sr. That worked for maybe 5 yrs. I forget sometimes because it was quite a few years ago. I should also mention I did not seek help until I was 35 or 26. I am now on Effector 300 MG and wellbutrin 300mg. This combination also worked for about 10 or 11 yrs. I have recently been having 2 to 3 week episodes if depression. I am so frustrated, this has taken many years of my life from me. Is there anyone who can shed some light my way. Thanks, Belinda