Hello! First post so I hope I am asking in the correct area. My MD increased my dose from 150 SR twice a day to 300 SR twice a day. I have been taking it for a few years. The pharmacy checked with her to see if it was a mistake but it's what she wants me to take. The max dosage is usual 450 Mg which I haven't tried yet. I am worried about seizures. I take it for fatigue and mild depression from the fatigue and ADHD. The 300 Mg was not helping with fatigue at all. I am on day 2 of this and so far it's fine except that I am not hungry but that's a plus. Thank you!