It shouldn't make a difference, as buprenorphine is not administered orally. This is because it undergoes first-pass metabolism, meaning that if you take it orally (i.e., swallow it), most of it will be metabolised in the GI tract into ineffective metabolites. This is why it's given in sublingual tablets (which melt in your mouth and are absorbed through the skin under your tonguee), transdermal patches, and solutions for IM or IV injection.
- Buprenex Information for Consumers
- Buprenex Information for Healthcare Professionals (includes dosage details)
- Side Effects of Buprenex (detailed)
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