... me taper down on Cymbalta and up on Brintillex. I've been on 20mg of Brintillex for almost a week and completely off Cymbalta. The only noticeable side effects have been a little nausea and increased flatulence. I actually feel really good and have tons more energy. One of the things that I read about Brintillex is that it is specifically prescribed for MDD, so it's a little concerning that other docs are prescribing it with other meds that may interact. I think Brintillex is a one and done type of drug. It's probably not a good idea to use it in combination with other psychotropic drugs, but that is purely my opinion. Based on what you all are seeing in this forum, what do you think?