I spent six weeks on Brintellix, increasing the dose from 10mg. to 20mg. at four weeks. No anti-depressant has ever made me so sick. I looked it up on Drugs.com and found out it was causing a horrible interaction with three of my other medicines that I must take. I was dangerously close to getting Serotonin Syndrome. I've had MDD my entire life and desperately need an antidepressant. The three "interacting" drugs are Fentanyl, Neurontin, and Ibuprofen. Aside from ECT, does anyone know what I could take without risking (what's left of) my life? I'm grateful for any ideas - thanks so much. alana