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Brexpiprazole - Should you take in am or pm?

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masso 4 Mar 2016

Possible side effects include somnolence and insomnia, therefore it is kink of hard to suggest when to take it.

Nervous system
In clinical trials in patients with major depressive disorder, the incidence of EPS-related adverse reactions, excluding akathisia, was 6% (3% in placebo patients). Akathisia occurred in 9% of patients (2% in placebo patients). The incidence of akathisia was dose-related. In clinical trials in patients with schizophrenia, the incidence of EPS-related adverse reactions, excluding akathisia, was 5% (4% in placebo patients). Akathisia occurred in 6% of patients (5% in placebo patients).[Ref]

Common (1% to 10%): Akathisia, headache, somnolence, tremor, dizziness, sedation, extrapyramidal-related events (excluding akathisia)[Ref]

Psychiatric
Common (1% to 10%): Anxiety, restlessness, abnormal dreams, insomnia[Ref]

The incidence of restlessness was dose-related in patients with major depressive disorder receiving this drug in combination with an antidepressant.[Ref]

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