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Breastfeeding - what are the side effects of ibuprofen 400mg while nursing?

Responses (1)

Rajive Goel 6 Jan 2012

Ibuprofen is a preferred choice as an analgesic or antiinflammatory agent in nursing mothers, because of its extremely low levels in breastmilk, short half-life and use in infants in doses much higher than those excreted in breastmilk,

Drug Levels

Maternal Levels. Two early studies attempted measurement of ibuprofen in milk. In one, the patient's dose was 400 mg twice daily, while in the second study of 12 patients, the dose was 400 mg every 6 hours. Ibuprofen was undetectable in breastmilk in both studies (<0.5 and 1 mg/L, respectively).

A later study using a more sensitive assay found ibuprofen in the breastmilk of one woman who took 6 doses of 400 mg orally over a 42.5 hours. A milk ibuprofen level of 13 mcg/L was detected 30 minutes after the first dose. The highest level measured was 180 mcg/L about 4 hours after the third dose, 20.5 hours after the first dose. The authors estimated that the infant would receive about 17 mcg/kg daily (100 mcg daily) with the maternal dose of approximately 1.2 grams daily. This dose represents 0.0008% of the maternal weight-adjusted dosage and 0.06% of the commonly accepted infant dose of 30 mg/kg daily (10 mg/kg every 8 hours).

There are no adverse effects of taking Ibuprofen when breastfeeding, however please also do talk to the doc for more clarity on the issue.

Take care, best wishes!

mkhoshafa 13 Jan 2012

thanks alot for answering.

Rajive Goel 14 Jan 2012

Most welcome.

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