... He was on Dilantin for seizures but was switched to Keppra. He is having severe edema or water rentention all over. Has anyone had an adverse reaction like this to Keppra. It is the only med that has been changed and edema started a few weeks after. His heart is fine we had that checked. I am just at a loss as to what to do. I can't find anythng referring to this on the adverse reaction websites. Please help. Thanks, from ycmc