Much of the material I read about choosing a depression medication discusses trying one after another for 6-8 week periods and seeing which one works. It sounds akin to throwing something onto a wall and "seeing what sticks". Paxil used to work for me but stopped after 8 or so years. The max dose of Cymbalta didn't help, and I don't know that I have multiple 6-8 week "tryout" periods left in me. I've also read about studies correlating patients' levels of serotonin, dopamine, and various other brain chemicals. If these levels can be measured, doesn't it make sense to check a patient's levels first, in order to make more of an informed, targeted medication regimen? Maybe this sort of testing is typical and I'm just unaware of it? If it is, what type of panel would I request?