I am bipolar and I have the most rapid forms if cycling. Everything can make me switch, including herbal remedies that are known or are just becoming known to be antidepressants. There must be thousands and thousands of people like me.
Why are we not employed to screen for substances that could be used as antdepressants? I mean only herbal remedies or chemicals that are already known to be non-poisonous. If say a thousand of us test the same substance and a unusual number starts to switch you know what you have at hand.
I don't find it unethical because I am confronted every day with substances that where not tested to be safe for me. I would prefere a more systhematic approach.