I have been on meds now for around 16 years and I feel like I have taken them all and none work. I'm currently taking a large combination of abilify lamitical, Zoloft Topamax trazodone plus more for pain for my nerve damage. I still have my high and low episodes I'm angry all the time I can't sleep to save my life and all I really want in life is to be happy. How come this disorder is so hard to manage. My anxiety is through the roof. Does anyone have any advice for meds.