I was switched to seroquel in the beginning of december in order to take water pills which are not compatible with lithium. A very bad decision for me, but was stuck between a rock and a hard place. I still feel like I am stuck in a manic mode for the last two months even though I have been off of seroquel now for over 2 months, I was on seroquel for only 30 days and now I can't sleep right. How long does seroquel stay in your system.