I was Rx'd Prazosin for anxiety 1 mg 3x day what are common side effects? I also take Metoprolol 100 mgs also
"Beta-blockers work by blocking the transmission of certain nerve impulses. The ends of some nerves release a chemical (neurotransmitter) called noradrenaline when the nerve is stimulated. This chemical then stimulates beta-adrenergic receptors. These receptors are tiny structures which occur on cells in various parts of the body including the heart, brain, and blood vessels. When these receptors are stimulated, they cause various effects. For example, nerve impulses to the heart can stimulate beta-adrenergic receptors on heart cells. This causes an increase in the force and rate of the heartbeat.
The beta-adrenergic receptors are also stimulated by adrenaline (epinephrine), a hormone which circulates in the bloodstream. Adrenaline is made in the adrenal gland. The blood level of adrenaline can vary. For example, you may release a lot of adrenaline into the bloodstream when you are frightened or anxious which can cause an increase in your heart rate, and other effects.
The beta-blocker medicine 'sits' on beta-adrenergic receptors and stops (blocks) the receptor from being stimulated. So, for example, if beta-adrenergic receptors in the heart are blocked, the force and rate of the heartbeat are reduced."
Interactions between your selected drugs
Applies to: metoprolol, prazosin
Using prazosin and metoprolol together can have increased effects on your blood pressure. You may be more likely to experience side effects such as dizziness, weakness, headache, flushing, fainting, and irregular heartbeat, especially if you have been on metoprolol and are starting treatment with prazosin. These effects may also occur following a dose increase of prazosin or when prazosin is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. You may need a dose adjustment or more frequent monitoring of your blood pressure to safely use both medications. Taking the prazosin dose just before going to bed may help. Avoid driving or operating hazardous machinery until you know how these medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Other drugs and diseases that your selected drugs interact with
metoprolol interacts with more than 400 other drugs and more than 10 diseases.
prazosin interacts with more than 200 other drugs and 2 diseases.
Interactions between your selected drugs and food
Applies to: metoprolol
Food can enhance the levels of metoprolol in your body. You should take metoprolol at the same time each day, preferably with or immediately following meals. This will make it easier for your body to absorb the medication. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking metoprolol. Metoprolol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
I do not have the same depth of knowledge about beta blockers as Masso, but I do take Prazosin 1 mg, t.i.d., and Metoprolol ER 25 mg q.d. I took Prazosin for years, prescribed by my rheumatologist. Initially I experienced some lightheadedness and dizziness, but that dissipated quickly as I got used to the medication. My cardiologist added the Metoprolol about a year ago with no apparent negative interactions. The combination has achieved the desired results hoped for from each specialist. I am guessing the dosage may make a difference when it comes to side effects. Also, taking the Metoprolol ER (extended release), may negate possible side effects. Good luck.
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