i.e. - is it better to take it with breakfast, lunch or dinner, or an hour or 2 before a meal??? I took it with a good meal about 11 am for the first dose ever (just started on it), and my sugar dropped to 50 about 3 hours later. I also take metformin 500 2 x / day. I just switched from actos to glipizide XL 2.5mg and this seems to be much more potent.