I started taking this about 3 years ago, used it consistently, and had fantastic results. I take this with a pill (minocyclin) as well. Not sure what I was thinking, but I discontinued use of the benzoyl peroxide/clindamycin combination about 4 or 5 months ago, thinking I was no longer dependent on it. Turns out I was, and I ended up breaking out like crazy about a month later. So now I've been back on it for about a month and a half. The first few weeks were awful; I continued to see new pimples and experienced severe dryness so I cut back to once a day and that helped, but my skin was still very very red and sore. Then it seemed to really begin to clear up my skin. However, just a few days ago as I entered my menstral cycle, I broke out pretty bad again. I've always broke out just a bit more than usual during that time of the month, but it's worse than it ever has been when I was previously on the cream. I'm just wondering how long I should wait to see real results, or if I should ask for a new prescription? Thanks!