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Can I take Benadry Allergy & Sinus with Venlafaxine 37.5MG?

Responses (1)

Anonymous 13 Apr 2012

Please read below the interreactions of these two meds. Hope this helps... Mary

Interactions between your selected drugs


diphenhydramine ↔ venlafaxine

Applies to: Benadryl Allergy Plus Sinus Headache (acetaminophen/diphenhydramine/phenylephrine), venlafaxine

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.


phenylephrine ↔ venlafaxine

Applies to: Benadryl Allergy Plus Sinus Headache (acetaminophen/diphenhydramine/phenylephrine), venlafaxine

MONITOR: Additive or synergistic effects on blood pressure and heart rate may occur when serotonin-norepinephrine reuptake inhibitors (SNRIs) are combined with sympathomimetic agents such as nasal decongestants, adrenergic bronchodilators, ophthalmic vasoconstrictors, and systemic vasopressors. The use of SNRIs alone has been associated with sustained increases in blood pressure and heart rate, and cases of elevated blood pressure requiring immediate treatment have been reported in postmarketing experience.

MANAGEMENT: Caution is advised if SNRIs are used with other drugs that can increase blood pressure and/or heart rate. Blood pressure and pulse should be measured prior to initiating SNRI therapy and monitored at regular intervals thereafter. Dose reduction or discontinuation of the SNRI should be considered in patients who experience a sustained increase in blood pressure or pulse rate.

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