Patients reach and maintain a steady-state serum concentration that is determined by individual variation in skin permeability and body clearance of fentanyl. So the amount of time it takes to get into the system is variable. It is released gradually into the system upon application and reaches a steady state between 12 to 24 hours.
Hope this helps,
- Fentanyl Information for Consumers
- Fentanyl Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fentanyl (detailed)
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