There are drug interactions between these medicines but if he has been taking this combination for a while and hasn't had any side effects he should be fine.
One thing is Depakote may increase the pharmacologic effects of phenytoin. Toxicity may result, despite normal phenytoin levels.
It may be more useful to monitor plasma free-phenytoin levels than to monitor total plasma concentrations. Just be aware and get him to see his doctor if he experiences symptoms of toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).
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