... and no bad effects. Late in 2014 I started to have very vivid dreams and my hands and especially my thumbs would be numb in the morning. Then I developed splits and fissures just on my thumbs which were very painful. I thought maybe the DW liquid? So I wore gloves. Didn't help. Started to eliminate my other meds. Nothing changed. Happened to find an old prescription bottle with Sandoz as the manufacturer. Currently, my atenolol is manufactured by Avkare. Could the formulation be different and causing my thumbs to bleed, and split and never heal?