Very strange -- The inside of the tops of my ears have changed to a strange dusky color. I believe it is from the long term use of Wellbutrin. I've been on 300 mg Wellbutrin for 10 years and my ears just turned a couple of months ago. My daughter also has major depression and has taken 450 mg for about 7 years. Her ears changed about a year ago -- I think hers changed sooner because her dosage was higher. We both take other depression and anxiety related medications, but Wellbutrin is the only one we have in common. Has this happened to anyone else? Our other prominent side effect has been hair loss.